A domestic survey showed that vaccination against the novel coronavirus infection (COVID-19) may have affected the development of deep vein thrombosis or cerebral vein thrombosis. Symptoms of frequent menstrual and uterine bleeding were also found to be related to vaccines.
The COVID-19 Vaccine Safety Committee of the Korea Medical Center announced the 3rd results of the scientific causality evaluation of adverse reactions after COVID-19 vaccination on the 11th.
First of all, the incidence rate of blood clots-related diseases such as deep vein thrombosis increased slightly after Pfizer vaccination. This is contrary to overseas research, so the possibility of overdiagnosis has also been raised.
As of the 21 days of risk period after Pfizer vaccination, the incidence of deep vein thrombosis increased 1.22 times, portal thrombosis 1.25 times, and pulmonary embolism 1.29 times.
Professor Jeong Jae-hoon of the preventive medicine class at Gachon Medical University and Professor Kim Gye-hoon of the Department of Circulatory Medicine at Chonnam National University Hospital, who conducted the study, said that further analysis of Pfizer vaccine is needed.
Professor Kim said, "Most studies abroad report that COVID-19 vaccination does not increase the risk of developing venous thromboembolism." In particular, there are no reports of association with the mRNA vaccine yet, he pointed out.
Professor Chung said, "The increase in the incidence rate is not confirmed when targeting all vaccines, but Pfizer vaccines are different from overseas research results, so there is a possibility of overdiagnosis," adding, "Additional analysis is needed."
Cerebral venous sinus thrombosis was also observed to increase the risk after inoculation in women and age groups aged 30 to 49 and 50 to 64.
Ahn Sang-joon, a professor of neurology at Catholic Kwandong University International St. Mary's Hospital, said, "The risk of occurrence is observed to increase statistically after vaccination. However, these results should be interpreted carefully considering research limitations such as diagnostic accuracy."
The causal relationship between abnormal uterine bleeding and the COVID-19 vaccine was evaluated as an "acceptance stage." In epidemiological studies, the risk of occurrence increased statistically after vaccination. The subjects of this epidemiological investigation are frequent menstruation and bleeding symptoms.
Whether the type of vaccine, abnormal uterine bleeding was significant. Considering the scientific evidence so far, including the results of this study and the review of the literature, the causal relationship between the COVID-19 vaccine and abnormal uterine bleeding is evaluated as an "acceptable stage.
Cho Si-hyun, a professor of obstetrics and gynecology at Gangnam Severance Hospital, said, "There is still little evidence to clearly identify the causal relationship between vaccines and abnormal uterine bleeding. However, according to several surveys and adverse studies, the risk of abnormal uterine bleeding after inoculation seems to increase statistically significantly. "
Writer: Yeyoung Jeon
(Picture from Unsplash)
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